Platelet-Rich Plasma

The Natural Filler — Platelet-Rich Plasma

Over the years, patients have approached Oculoplastic surgeon Dr. Amiya Prasad, M.D. and expressed their desire for a natural facial filler with no risk of allergic reaction. His response to such requests involve the process of using platelet-rich plasma or PRP. Often referred to as a “vampire facelift” or the “Dracula facelift”, platelet-rich plasma makes use of a patient’s own blood to rejuvenate their own appearance in a similar way that popular fillers such as Restylane does.  This procedure is not a surgical facelift nor does it create the same effect as a facelift. The procedure helps restore or enhance areas which require volume.

How Does Platelet-Rich Plasma Treatment Work?

Dr. Amiya Prasad has been using the process of platelet-rich plasma to enhance and restore the skin of the face and neck. Platelet-rich plasma contains growth factors which stimulate your body to repair and restore tissues using your body’s own natural processes. It also exhibits wound and soft tissue healing. With his technique, Dr. Prasad is able to rejuvenate your skin by isolating elements from your blood which can then be injected below wrinkles, folds and even acne scars with the intention of healing them without the risk of allergic reactions.

In face Dr. Prasad also uses platelet-rich plasma to accelerate recovery from and to enhance the results of rhinoplasty, facelift, fat transfer and facial implant surgery.

Platelet-rich plasma can be used for the following:

  • Improve the glabellar lines (the number 11 sign between the brow)
  • Improve the forehead lines
  • Improve the appearance of periorbital lines (crow’s feet)
  • Improve nasolabial folds
  • Improve smile lines
  • Treat acne scars
  • Improve the vertical lip lines (lipstick lines)
  • Improve the marionette lines (the ones from the corners of the mouth to the chin)

The Platelet-Rich Plasma Treatment Process

After determining that platelet-rich plasma (PRP) or Selphyl platelet rich fibrin matrix (PRFM) is right for you, a small amount of your blood will be drawn, similar to having basic blood tests at your doctor’s office. Dr. Amiya Prasad uses platelet-rich plasma (PRP) with Selphyl® technology (an FDA cleared device to separate the elements of your blood in a specific way) to generate a platelet-rich fibrin matrix (PRFM). This Selphyl® PRFM primarily contains fibrin, a natural blood protein, and platelets, the part of your blood chiefly responsible for stopping bleeding.

The blood drawn from the patient will then be used to prepare the Selphyl® PRFM in a 6-minute process. During that time, the areas of the face that are to be treated will be cleansed and numbed, either with a topical cream or spray or with a small injection. Once this is done, the platelet-rich plasma (PRP) or Selphyl® PRFM is injected into the skin to be treated. Cold compresses are then applied to these areas. The entire process typically takes no more than 15-20 minutes.

What To Expect After Platelet-Rich Plasma Treatment

Immediately after treatment, expect the treated area to look slightly red, though this typically fades in a few hours. There is usually very little bruising, which is generally limited to a few “points” and can easily be covered with make-up. There will be some mild swelling, which in most patients fades in a few days. Beyond this, there is usually some “settling” of effect over the first 1-2 weeks, after which the improvements noted are long lasting.

Before and After Photos for Platelet-Rich Plasma Cases

Shown here are before (left) and after (right) views of actual patients. It’s important to remember that every patient responds differently to surgery, and no one can be certain that he or she will get the exact results shown. However, these photos will illustrate the changes that are possible with these procedures.

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Click here for transcript.

You asked:

Are My Under Eye Circles and Hollows Related to Sinuses/ Deviated Septum? Could Restylane Help?

I’m in my late 20’s and recently moved to a high altitude, dry climate. I’ve had subtle circles for awhile, but in the last year they’ve gotten much worse. They are a purple/blue and also sunken/hollow, particularly around the tear trough. I’ve been having nasal congestion issues during sleep, so I saw an ENT who diagnosed a deviated septum. I’ve been having nasal congestion during sleep, so I saw an ENT who diagnosed a deviated septum. My questions are: could the congestion/ deviated septum be related to the circles/ sunken look? If so, would a septoplasty correct them? Would Restylane be a good option for me?


Thank you for your question!

Essentially, you’re wondering whether the situation where you have a deviated septum and any type of sinus related issue is affecting the under eye area. And of course, being you’re young, we naturally can assume that this is an age-related situation.

Well, from the photos you submitted, it’s clear that you have very light skin and there isn’t a lot of fat on that under eye area. Basically, the area from the eyelid to the cheek, we refer to the eyelid-cheek junction or a transition point of the tear trough area is an area with some variability. And a lot of people are just genetically very very thin in this area. And what we end up seeing is a relatively bluish color to this area because basically looking through skin that’s almost transparent. And so you’re seeing the bluish color of the blood vessels.

So the question about the relationship between the under eye area and the sinuses, there is some relationship but it is usually more of a fluid-type of relationship and what the means essentially is whenever the sinuses get congested or there’s allergies, there’s actually a common pathway where everything drains and it’s behind the eye. So, very often that area can have some fluid. Now in your case, that’s not what we’re talking about. With you, it’s more about the thickness of the tissue and the volume in that area.

So an approach that we offer in our practice, we look at this area in a couple of different ways. One, we look at the cheek area and see if any volume may be added to the cheek. Now when you’re young, we’re not interested in having you do a lot of procedures that are typically more age-related procedures. However, conservative options may be something worth entertaining.

So in our practice, we do procedures such as the use of platelet rich plasma or platelet rich fibrin matrix to help add some collagen and some quality to the skin. This is a very leading edge type of work that we’ve been applying in other areas of our practice including the hair loss division of our practice. But platelet rich plasma is actually your own blood and it is spun down so we have this pure platelet concentration that has growth factors. And a lot of times, these growth factors work very well in improving the skin quality and building the collagen under the skin. In addition to this, we also routinely use hyaluronic acids such as Restylane to add some volume, to help soften that tear trough area.

My advice is to consider how committed you are to doing something in the short term and these procedures can basically last anywhere from 6 months to a year but does vary from individual to individual.

So as far as answering the question about the sinuses, of course manage your sinuses and deviated septum as per your EENT doctor but I wouldn’t expect too much of a dramatic change in the skin quality under the eyes and it should potentially addressed with a variety of different approaches using your natural as well as your injectable filler. So I hope that was helpful and thank you for your question.


Click here for a recent article published in the journal “Journal of Drugs in Dermatology” about Platelet-Rich Plasma

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